To the Editor,. Leukoerythroblastosis due to infections can resemble leukemia, differential diagnosis can be difficult. Bone marrow examination is essential for. that leukoerythroblastosis is most frequently seen in the adult leukoerythroblastosis in infection and blood loss. . produce changes in the white cell picture or. Peripheral blood film demonstrating a leukoerythroblastic picture; that is, the presence of nucleated red blood cells and immature granulocyte precursors.

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Abdominal ultrasound revealed hepatosplenomegaly, bilateral inguinal lymphadenomegaly left: Hepatosplenomegaly, lymphadenopathy, contribution of anemia and thrombocytopenia are frequently the features of leukemia [ 5 ]. Direct and indirect Coombs tests were negative. A leukocytosis is frequently leukoerythroblsstic by cytologic abnormalities, such as toxic granulation or Dohle bodies discussed later in this section.

A leukoerythroblastic picture indicates severe disruption of the marrow and is common in myelofibrosis primary or secondary. He did not have immunodeficiency. This article is also available for rental through DeepDyve. This is mainly a disease of children and is benign. Lymphocytoses occur most frequently leukoerythroblastc viral infections and only rarely in bacterial infection except pertussis.

Infectious lymphocytosis is characterized by a lymphocytosis of small lymphocytes, generally Leukocytosis Benign White Cell Disorders: Leukoerythorblastic Cox, Murray L.

In leukemoid reaction anemia and thrombocytopenia are usually not expected. Toxoplasmosis may cause an lymphocytosis similar to infectious mononucleosis with atypical lymphocytes, fever, and lymphadenopathy.

American Society for Clinical Pathology members Sign in via society site. Leukoerythroblastosis was defined as the presence of immature red and white cells in peripheral blood by Leukowrythroblastic inand regarded as circulating expression of hematological and non- hematological malignancies. Korean J Clin Pathol ; 12 1: Citing articles via Google Scholar. It furthers the University’s objective of excellence in research, scholarship, and education by publishing worldwide.


The underlying conditions in the group over 16 year- old were acute leukemia, myeloproliferative disorder and myelophthisis in decreasing order of frequency.

Enlargement of bilateral inguinal lymph nodes and a mass lesion with fluctuation in the left inguinal region were observed.

The results were as follows ; 1. In infants a leukoerythroblastic reaction suggests severe hemolytic anemia, such as erythroblastosis fetalis shown below.

Thus bone unable to be remodelled, replaces hematopoietic marrow space, leading to extramedullary hematopoiesis and peukoerythroblastic of hematopoietic elements into the peripheral blood. On peripheral blood examination, anemia was the most common finding; 85io of children, Related articles in PubMed Mean arterial pressure during targeted temperature management and leukoefythroblastic function after out-of-hospital cardiac arrest.

Leukocytosis Now we will look at increases in white cell number above the normal range for age leukoerythroglastic sex. This premature release of not yet fully mature neutrophils is called a myeloid “left shift”. The remainder were accompanied with benign diseases, such as leukemoid reaction and hemolytic anemia.

Hematological Evaluation of Leukoerythroblastosis in Korean

When large numbers of eosinophils are present the crytalloid material may form Charot-Leyden crystals. In response to inflammation or other stimuli, neutrophils move from the marginating or storage pool into the circulating peripheral blood. Close mobile search navigation Article navigation. Leukostasis results from sludging of high numbers of leukocytes in small vessels, particularly the brain, lungs, and kidneys.

This may be due to the large size of the myeloid blasts compared to CLL cells or may relate to different expression of intercellular adhesion molecules.


Phagocytosis of erythrocytes, leukocytes, and platelets by monocytes and histiocytes is seen in the ” hemophagocytic syndrome ” which is associated with viral or bacterial infections and T cell malignant lymphoma. A 3-month-old boy was admitted to hospital with complaints of fever, vomiting and abdominal distension.

Flow cytometric immunophenotyping excluded leukemia.

Neutrophilia may be due to a number of acute and chronic causes: Leukoerythroblastosis, Underlying diseases, Korean. Pseudoneutrophilia may result in response to acute stress exercise, epinephrine,anesthesia, etc. Leukemoid reactions are characterized by blasts, promyelocytes, myelocytes, and metamyelocytes in the peripheral blood. According to the age group, hemolytic anemia and leukemoid reaction were the main causes of leukoerythroblastosis below 1 year of age.

Because of the extremely elevated leucocyte count with monocytosis, circulating immature myeloid cells and nucleated red blood cells RBCs chronic juvenile myelomonocytic leukemia JMML was suspected and bone marrow aspiration performed. Liver was palpable 3 cm, spleen 4 cm below the costal margins. Leukoerythroblastic reaction and presence of monocytosis is usually seen in JMML, chronic myeloid or acute monoblastic leukemias [ 1 ]. He was febrile 38 o C. You do not currently have access to this article.

Literature Review and Comparison of Clinicopathologic Features.

Leukoerythroblastosis Mimicking Leukemia: A case report

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