Granuloma inguinale is a genital ulcerative disease caused by the intracellular gram-negative bacterium Klebsiella granulomatis (formerly. the causative organism was similar to Klebsiella species and reclassified the gram-negative pleomorphic bacillus as Klebsiella granulomatis. Granuloma inguinale is a sexually transmitted bacterial disease caused by Klebsiella granulomatis. It is seen most commonly in sexually active.

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Erythromycin and lincomycin both give good results in donovanosis although only a few trials have been conducted and experience is limited.

As a result, it is recommended to apply low concentration of antibiotics to induce prophylactic measures to prevent bacterial infections, as also recommended by other researchers Sheebha et al. Retrieved from ” https: Granuloma inguinale is a clinical diagnosis supported by the presence of Donovan bodies in smears from the lesion.

Complications include tissue destruction, scarring, the development of genital lymphoedemahaematogenous dissemination to bones and viscera and squamous carcinoma.

From Wikipedia, the free encyclopedia. J Clin Microbiol ; The microbes were isolated from silkworm haemolymph. Isolation and characterization of pathogenic bacterial species in the silkworm, Bombyx mori L.

In this study the microorganism was identified as a number of the genera Klebsiella granulomatis bacterium. Klebsiella granulomatis gram-negativeaerobic, encapsulated Route of transmission Sexual transmission Autoinoculation of adjacent skin Perinatal transmission Risk factors Men who have sex with men Uncircumcised men Low socioeconomic status References: Administration of antibiotics and dose of administration are critical as in many cases administration of antibiotics was reported to have detrimental effects on intestinal micro-flora of silkworms which cause adverse effects on the physiological system Subramanian et al.

Conflict of interest The authors declare that they have no conflict of interests. Diagnosis of granuloma inguinale is based primarily klebziella clinical findings and is confirmed through detection of Donovan bodies intracytoplasmic macrophages containing bacteria in ulcer smears or biopsies.


The cultivation from granuloma inguinale of a microorganism having the characteristics of Donovan bodies in the yolk sac of chick embryos. On the strength of available evidence ampicillin cannot be recommended as first line treatment. Identification of a pathogenic bacterium, Staphylococcus gallinarum, to Bombyx mori.

Conclusion This study reports for the first time about bacterial flacherrie infection of silkworm in Bangladesh and K. This Gammaproteobacteria -related article is a stub. Spread to local lymph nodes is followed by ulceration of skin overlying the lymph nodes.

Abstract Bacterial disease of silkworm causes significant reduction of silk production leading to huge economic loss. Temperature koebsiella pH influence bacterial growth.

At 48 h, organisms resembling Donovan bodies klebskella identified in monolayer cultures from all three specimens. It is now possible to test in vitro susceptibility of C. In other projects Wikispecies. Effect of prophylactic antibiotic treatment granulomaris the growth and cocoon characteristics of Bombyx mori L. Prepare and succeed on your medical exams. Global eradication of donovanosis: Special Situations Disseminated Infection Hematogenous disseminated spread is a life-threatening complication of donovanosis.

Klebsiella granulomatis is Gram-negativerod-shaped bacterium of the kebsiella Klebsiella [1] known to cause the sexually transmitted disease granuloma inguinale or donovanosis. Granuloma inguinale in Northern Queensland.

Characterization of Klebsiella granulomatis pathogenic to silkworm, Bombyx mori L.

Sequencing reactions were carried out using ABI-Prism Big dye terminator cycle sequencing ready reaction kit and the PCR products were purified by a standard protocol. Many previous studies reported isolation of bacteria of different genus granu,omatis diseased silkworm, such as, Acrobacter cloacaeAchromobacter superficialisAchromobacter delmarvaePseudomonas boreopolis, Pseudomonas ovalisEscherichia freundii and Staphylococcus albus Chitra et al.


Many of the reported cases of haematogenous dissemination have been linked to tearing during delivery of an infected granulomatix lesion. By using this site, you agree to the Terms of Use and Privacy Policy. Effect of application of amoxicillin and ampicillin on the commercial parameters of silkworm Bombyx mori L. Silkworm, Pathogenic bacteria, Klebsiella pneumoniaeHaemolymph, Antibiotic. Surgical treatment may be necessary for patients who develop genital pseudoelephantiasis, a complication seen most commonly in women.

Ceftriaxone in the treatment of chronic donovanosis klbesiella central Australia. Donovanosis has been associated with an increased risk of HIV infection.

Granuloma Inguinale (Donovanosis)

Pathogenicity of the isolate to silkworm Larvae of hybrid strain B. Rake G, Dunham W. Good results in the treatment of pregnant women using combined erythromycin and lincomycin have been reported from Australia 3. Over the last twenty years the prevalence of donovanosis has decreased significantly and few cases are reported nowadays even in countries where the prevalence was once high.

Sex Transm Dis ; Calymmataobacterium granulomatis is an intracellular organism which causes an ulcerating sexually transmitted infection, known as donovanosis or granuloma inguinale 1. Only three papers report results of in vitro experiments with chemotherapeutic agents 612 According to an estimate, livelihood of about 0.

Fifty healthy newly moulted fifth-instar larvae were included in each experimental group. As a result, bacteria associated with silkworm are prone to develop resistance to commonly used antibiotics.

Broad spectrum antibiotics viz.