Capitulo 1 – Download as PDF File .pdf), Text File .txt) or read online. Introducao-Bioestatística – Uploaded by. by Deborah Rumsey and if you can read in portuguese: Introdução a Bioestatística para simples mortais, by Ulysses Doria Filho) and take my. . -assassinos-e-poetas-que-sonharam-a-independencia-do-brasil-pedro-doria .

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Moving on… The eligible patients were divided in three groups: Go hit the books then. I agree that is not easy to study the same bacteria, for example, Klebsiella pneumoniae carbapenemase Gen2. Therefore, beer drinkers have lower mortality than sober patients. S Army — Delta associates — Memegenerator.

Combination therapy for non-believers, and believers too! The ART trial and how lung recruitment died. Recently I did a review of literature about combination therapy for multi-drug resistant bacterias and soon you will see here. Keep this in mind!

Meaning, if you wanna treat them, do it with the right dose! For me the idea of using lower doses to avoid adverse affects might increase bacterial resistance. Another thing is to realize that the study compares different sites of infection and different bacterias.

Combination therapy for non-believers, and believers too! – ICU Revisited

Patients bioestatisyica the validated polymyxin combination therapy had more severe infections and more serious disease, monotherapy group was older. Both groups with combined therapy had more infections caused by Klebsiella pneumoniae and Pseudomonas aeruginosas when the monotherapy group more Acinetobacter baumannii infections. The antibiotic dose was included in the multivariate model.


Data and results Patients in the validated polymyxin combination therapy had more severe infections and more boiestatistica disease, monotherapy group was older. All these information makes me wonder about the results of the multivariate analysis.

There it is, nebulized and intravenous are the same?

From a statistical point of view, the drinker only begin to exist at day This is gonna be a revolving theme here, so keep your eyes open! Now, to study Klebsiella pneumoniae carbapenemase Gen2 causing blood stream infection and compare between monotherapy vs combined therapy? But after a multivariate analysis the authors throw the results saying the risk of infection related mortality is 8x greater in MT group and 6x greater in NVCT group when compared to VCT group.

In their majority, the most cited, are observational trials. Interestingly, was considered polymyxin use any of: Is that honest to compare this group with others?

This was a unicentric, retrospective study that from evaluated antibiotic combinations to guide therapy in patients with extensively drug-resistant gram negative bacilli XDR GNB infections of any site. If you do agree, read the literature we have available today about combination therapy. Therefore, if you read an article showing a possible association between combined therapy and lower mortality and take this as true I can recommend you two books Statistics for Dummies, by Deborah Rumsey and if you can read in portuguese: Nothing but the whole truth.

Combination therapy for non-believers, and believers too!

The only group which received polymyxin at adequate dose was the VCT group. I can show you that a patient who drinks beer at 5th day of ICU have lower introdko than a patient who does not. And also other strange dlria happened. Is the HCAP concept a lie?

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Why I hate tramadol but sometimes use it. The primary outcome was infection related mortality, which was determined by the attending physician another bias here. The median of adequate treatment for monotherapy group was ZERO! Take another look at the antibiotics doses table. Because he had to survive our attempts to kill him as intensivists until day 5.

Patients were included if: So, if I begin with polimyxin and just after 3 days add amikacin, this guy who recive amikacin is the same that our 5th day drunk guy. Even if the patients in the VCT group were more sick, it was the only group which received adequate dose treatment.

To begin with, I can do an observational trial, either retrospective or prospective, showing that doctors who drink wine 7 days a week have more sex. One interesting fact is that even with lot of difference among polymyxin doses ulyases difference in nephropathy RIFLE was showed. Here we have a problem, Immortal Time Bias.