Hydrotropic Solubilization. Priyanka Arjaria1, Manoj Goyal2, Suman Jain3. 1Shri Ram College of pharmacy,Banmore,Morena, India, 2IPS College of pharmacy. Purpose. This study examines the mechanism of hydrotropic solubilization using the riboflavin-nicotinamide system. The most commonly proposed mechanism. On the other hand, planarity of the hydrophobic part has been emphasized as an important factor in the mechanism of hydrotropic solubilization. Solute consists.

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View at Google Scholar S. Adenosine triphosphate ATP has been shown to be a hydrotrope able to prevent aggregation of proteins at normal physiologic concentrations and hydrotropoc be approximately an order of magnitude more effective than sodium xylene sulfonate in a classic hydrotrope assay.

For example sodium benzoate, urea, sodium salicylate and ibuprofen sodium etc.

hydrrotropic Journal of Pharmacy Research ; 3 3: Earlier, many techniques have been developed for enhancing solubility of drugs. The type of anion or metal ion appeared to have a minor effect on the phenomenon. Therefore, solubility is one of the important parameter solubiliztaion be considered in the product development in order to achieve desired concentration of drug in systemic circulation which further gives effective pharmacological response.

Actually, low aqueous solubility was the major concern for Lumefantrine; hence by the use of solubilizatiob solubilization technique not only solubility, dissolution rate increased but also there would be good scope of increase in bioavailability of Lumefantrine. How to cite this article: Hydrotropes are a class of chemical compounds which affect an increased aqueous solubility by several folds to certain solutes which are sparingly soluble in water under normal conditions.

Hydrotrope – Wikipedia

As most of the drugs available are poorly aqueous soluble, solubility enhancement has become major challenge to the formulators in the product development of many orally administered drugs. Such as tinidazole, metronidazole and salicylic acid using sodium benzoate and sodium citrate.

It is used in muscular, skeletal, and joint disorders such as osteoarthritis and rheumatoid arthritis. Solubliization Journal of Pharmaceutics ; Solubility enhancement ratio was calculated by using following formula: Solubility Studies using Hydrotropes: The results of analysis obtained by solubilizatioj proposed method are comparable with the results of analysis obtained by the Indian Pharmacopoeial method.


This is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Then, few mg by visual observation of fine powder of drug was transferred to the bottle. When the determined solubility enhancement ratio was at least 5, such hydrotropic solution was selected for that drug.

Common products containing a hydrotropes include laundry detergents, surface cleaners, dishwashing detergents, liquid soaps, shampoos and conditioners. This eolubilization an open access paper distributed under the copyright agreement with Serials Publication, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

A Promising tool for solubility Enhancement”, Int J. Apart from those, hydrotropic solubilization is one of the solubility enhancement techniques applicable to enhance solubility of hydrophobic drugs with the use of hydrotropes like sodium benzoate, urea, piperazine etc.

Dahima R and Gangwal S: Solute consists of alkali metal salts of various organic acids. Physical Pharmacy, New Delhi, B.

The solubility study was carried out in triplicate and the results were solubilizatioh in Table 5. Here, diamond is the preferred choice for most applications because of its robustness and durability.

Digest Journal of Nanomaterials and Biostructures ; 5 1: Urea and Ammonium acetate were purchased from Qualigens, Mumbai, India.


Enhancement of water solubility of felodipine by preparing solid dispersion using poly-ethylene glycol and poly-vinyl alcohol. Lornoxicam is completely insoluble in water but soluble in alkaline solutions. Sodium benzoate is cheaper than most of the organic solvents and thus may be a better substitute for expensive organic solvents that are used in routine analysis of pharmaceuticals.

A simple spectrophotometric estimation of Ketoprofen in tablets using mixed hydrotropy.

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It is then neutralized with a base. There was more than 15 fold enhancement in aqueous solubility of benzoic acid in 1.

Application of mixed- hydrotropy to develop injection dosage forms of poorly water-soluble drugs. The process of solubilisation involves the breaking of inter-ionic or intermolecular bonds in the solute, the separation of the molecules of the solvent to provide space in the solvent for the solute, interaction between the solvent and the solute molecule or ion. Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin B 2 in aqueous solution.


Institute of Technology and Science, Indore Solubility indicates the maximum amount of a substance that can be dissolved in a solvent at a given temperature. Indian Journal Pharmaceutical Science ; solubilizaion 6: Preparation of topical solutions of poorly water-soluble drugs, precluding the use of organic solvents.

The percentage recovery was found to be The study on solubility yields information about the structure and soulbilization forces of drugs. Quantitative estimations of poorly watersoluble drugs by UV-Visible spectrophotometric analysis precluding the use of organic solvents.


Solubility of Lumefantrine in various hydrotropes was also solubiilization in graphical form in Fig. Therapeutic efficacy of a drug depends upon its bioavailability and ultimately its solubility to achieve a desired concentration in systemic circulation.

The standard deviation, coefficient of variance CVand standard error were calculated for the drug.

Jayakumar C, Deepak Kumar K, Nesakumar D, Nagendra Gandhi N[15] were performed titrimetric estimation has been developed using 2 M sodium salicylate as a hydrotropic solubilizing agent for the quantitative determination of theophylline in bulk, a sparingly water?

The lipophilic drug solubilizatikn reaches market requires a high dose to attain proper pharmacological action. From Wikipedia, the free encyclopedia.

Biochem Z ; Because of their low aqueous solubility and high permeability, dissolution from delivery systems forms the rate limiting step in their absorption and systemic bioavailability [ 23 ]. The solubility enhancement ratios for drug in different hydrotropic solutions were calculated and the results were shown in Table 7.