Granulosis rubra nasi is a rare condition characterised by hyperhidrosis of the nose. Granulosis Rubra Nasi (GRN) is a rare disorder of the eccrine glands. It is clinically characterized by hyperhidrosis of the central part of the face. Granulosis rubra nasi is a rare familial disease of children, occurring on the nose, cheeks, and chin, characterized by diffuse redness, persistent excessive.

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Hirsutism Acquired localised generalised patterned Congenital generalised localised X-linked Prepubertal. The initial presentation is excess sweating of the tip of the nose with small visible beads of sweat With time erythema, papules, vesicles and telangiectasia rubea develop over the nose, cheeks, upper lip and chin. Recently, use of botulinum toxin A that induced long-term remission in a patient with GRN was described by Grazziotin et al.

Granulosis rubra nasi – Wikipedia

Author information Copyright and License information Disclaimer. The differential diagnosis like rosacea or perioral dermatitis can be considered. Proc R Soc Med. It is clinically characterized by hyperhidrosis of the central part of the face, most granulosls on the tip of the nose, followed by appearance of diffuse erythema over the nose, cheeks, chin, and upper lip.

Granulosis rubra nasi: a rare condition treated successfully with topical tacrolimus

To receive news and publication updates for Case Reports in Dermatological Medicine, enter your email address in the box below. Ueber die Beziehungen des Hidrocystoms zur Granulosis rubra nasi.


National Center for Biotechnology InformationU. This chapter is set out as follows: Moreover, she showed excellent response to topical tacrolimus, a finding not observed in literature. Acrokeratosis paraneoplastica of Bazex Acroosteolysis Bubble hair deformity Disseminate and recurrent infundibulofolliculitis Erosive pustular dermatitis of the scalp Erythromelanosis follicularis faciei et colli Hair casts Hair follicle nevus Intermittent hair—follicle dystrophy Keratosis pilaris atropicans Kinking hair Koenen’s tumor Lichen planopilaris Lichen spinulosus Loose anagen syndrome Menkes granuosis hair syndrome Monilethrix Parakeratosis pustulosa Pili Pili annulati Pili bifurcati Pili multigemini Pili pseudoannulati Pili torti Pityriasis amiantacea Plica neuropathica Poliosis Rubinstein—Taybi syndrome Setleis syndrome Traumatic anserine folliculosis Trichomegaly Trichomycosis axillaris Trichorrhexis Trichorrhexis invaginata Trichorrhexis nodosa Trichostasis spinulosa Uncombable hair syndrome Wooly hair Wooly hair nevus.

A 20 years-old girl presented with multiple discrete asymptomatic reddish vesicles over cheeks, nose, and forehead for four years Figure 1.

These granulsis disappear on diascopy and reappear on relieving pressure [ 2 ]. Histology shows dilation of dermal blood vessels and lymphatics with perivascular lymphocytic infiltration and dilation of sweat ducts. GRN is believed to be an inherited condition. This erythema may be studded with sweat droplets, giving damp glistening appearance.

On follow up after three weeks, size of the vesicles had decreased and patient stated no increase in size of the vesicles, even on sun exposure. Granulosis rubra nasi is a rare disorder of the eccrine glands first described by Jadassohn in Pilosebaceous units are normal and no heterotopic apocrine glands are found[ 3 ] This disease usually remits after puberty, unlike the primary forms of localized hyperhidrosis but sometimes may continue into adulthood.


The differential diagnosis includes rosacea and perioral dermatitis.

National Center for Biotechnology InformationU. Indian Dermatol Online J.

Granulosis rubra nasi

GRN is nasl rare disorder. Histopathology from the vesicle showed mononuclear cell infiltration in the upper dermis, especially around eccrine sweat apparatus, along with dilatation of superficial capillaries and lymphatics. We here report a case of GRN having lesions persisting in adulthood.

Some authors have suggested a defect naasi vasomotor and secretory functions of the nose. Persistent localized hyperhidrosis of central face is the main cause for this condition [ 6 ]. By using this site, you agree to the Terms of Use and Privacy Policy.

Granulosis rubra nasi | Primary Care Dermatology Society | UK

Ingrown nail Anonychia ungrouped: Hyperhidrosis and botulinum toxic in dermatology. Open in a separate window. A Patchy mononuclear cell infiltration in upper dermis with dilatation of capillaries and lymphatics Haematoxylin and Eosin stain x ; B patchy mononuclear cell infiltration with dilatation of capillaries and lymphatics Haematoxylin and Eosin stain x ; C mononuclear cell infiltration around sweat duct Haematoxylin and Eosin stain x The infundibular and sebaceous ducts are plugged with stratum corneum and villous hair follicles.