Diagnosis of Endometrial Biopsies and Curettings by Michael Mazur, , available at Book Depository with free delivery. Diagnosis of Endometrial Biopsies and Curettings: A Practical Approach. Veli Marjoniemi. x. Veli Marjoniemi. Search for articles by this author. Department of. Generally, this should comprise a formal curetting rather than an outpatient biopsy. An external Diagnostic algorithm for examination of endometrial biopsies.

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These are benign proliferations, and in this situation the presence of architectural complexity does not signify a hyperplastic process. The use of tamoxifen as a prophylactic agent in endometril with a family history of breast cancer is now being investigated.

Many endometrial epithelial metaplasias occur without obvious causation. Generally, this should comprise a formal curetting rather than an outpatient biopsy.

Am J Surg Pathol 8 — Pathology of endometrium treated with tamoxifen. Mod Pathol 14 — Looking for beautiful books?

This pseudodecidualisation is often most prominent just beneath the surface glands and diaynosis usually accompanied by an inflammatory cell infiltrate, largely comprising natural killer cells. As the effects of tamoxifen on the endometrium are believed to be due to oestrogenic activity, it is expected that most endometrial cancers should be endometrioid in type, as these neoplasms are hormone receptor positive.

The risk of developing an endometrioid adenocarcinoma after a diagnosis of atypical endomertial is difficult to ascertain, as, once atypical endometrial hyperplasia is diagnosed, it is treated either hormonally or more usually surgically. In a simple hyperplasia, the normal gland to stroma ratio is maintained or there is slight increase. In these circumstances, successful pregnancies have ensued, bikpsies there is a high risk of subsequent recurrence of hyperplasia or carcinoma.

My approach to the interpretation of endometrial biopsies and curettings

Appl Immunohistochem 5 — National Center for Biotechnology InformationU. In this review, I will outline my approach to the interpretation of endometrial biopsy specimens, especially concentrating on areas which, in my experience, create difficulties for pathologists. Assessment of nuclear atypia is extremely subjective, resulting in marked interobserver variation, even among specialist gynaecological pathologists, in the classification of endometrial hyperplasia. Cancer 56 — When florid, this may be suggestive of a serous carcinoma or an EIC.


Int J Gynecol Pathol 8 — An endometrioid carcinoma with a papillary growth pattern may be misdiagnosed as a serous carcinoma and, conversely, serous carcinoma with a glandular growth pattern and little or no papillary curettinhs may be mistaken for an endometrioid carcinoma. When an endometrial biopsy is carried out for abnormal uterine bleeding, the pathologist should always consider the possibility of a polyp. Two Extraordinary Sellar Neuronal Tumors: The residual atrophic glands are negative.

Int J Gynecol Cancer 10 — As referred to previously, serous carcinoma and its presumed precursor lesion EIC also variously termed endometrial carcinoma in situ or surface serous carcinoma have a marked propensity to arise in or to be associated with otherwise benign endometrial polyps. Epithelial metaplasias are, however, especially likely to be seen in endometrial polyps and in association with hormonal preparations.

Royal Society of Medicine Press Ltd, The main alternative diagnostic consideration on endometrial biopsy is likely endomstrial be an endometrioid adenocarcinoma showing myometrial infiltration.

Tamoxifen is widely used as adjuvant therapy in the management of curetings cancer. Adv Anat Pathol 11 — J Clin Pathol 58 1—6.

With this artefact, the glands become moulded together and often there is tearing of the tissue around the glands, which is a clue to the artefactual nature.

My approach to the interpretation of endometrial biopsies and curettings

Table of contents Introduction. Potential benign mimics of endometrial hyperplasia Artefacts. Am J Clin Pathol 99 — The pathological diagnosis is generally straightforward if the gynaecologist is aware of the presence of a polyp, has conveyed this information to the pathologist and has removed the polyp intact. The value of ancillary techniques, especially immunohistochemistry, is discussed where appropriate. Indeed, as discussed previously, there is a peculiar tendency for serous carcinoma and EIC to arise within endometrial polyps, whether sporadic or associated with tamoxifen.


Diagnosis of Endometrial Biopsies and Curettings : Michael Mazur :

Gynecol Oncol 55 — With a thickened endometrium, a focal lesion or a strong clinical suspicion of major pathology, however, a scant specimen may be an indication of the need for repeat biopsy. Some endpmetrial these may be misinterpreted as endometrial hyperplasia or even as carcinoma if not appreciated to be artefactual. World Health Organization classification of tumours. Endometrial hyperplasia In my experience, various aspects related to endometrial hyperplasia commonly create problems for pathologists.

The glands are lined by markedly atypical nuclei, characteristic of serous neoplasia. Diagnosis of Endometrial Biopsies and Curettings: If you eendometrial registered with a username please use that to sign in.

We use cookies to give you the best possible experience. Adv Anat Pathol 9 — Lymphocytes, including natural killer cells and lymphoid aggregates, are a normal component of the endometrium, and polymorphs are characteristic of the premenstrual and menstrual phases. Caution should be exercised in diagnosing a proliferative endometrium in the absence of mitoses, although these may be few in number. Int J Gynecol Pathol 21 — A report of 27 cases. Adenofibroma and adenosarcoma Adenofibroma, with a benign stromal component, and adenosarcoma, with a malignant one, are two of the mixed epithelial and mesenchymal mixed Curettints tumours of the uterus.

Polyp cancers may be endometrioid in type, but serous proliferations, biopeies carcinoma or its precursor lesion endometrial intraepithelial carcinoma EIChave a particular propensity to arise in or be associated with otherwise benign endometrial polyps.

Tamoxifen curettlngs the endometrium. Mod Pathol 3 —