The Milan criteria are a generally accepted set of criteria used to assess suitability in patients for liver transplantation with cirrhosis and hepatocellular carcinoma. Avaliação do tratamento dos nódulos do hepatocarcinoma nos pacientes em lista entre pacientes incluídos no Critério de Milão ou ao downstaging (p= 0,). .. Yan L. Downstaging advanced hepatocellular carcinoma to the Milan criteria. Catorze diferentes critérios foram encontrados e descritos em detalhes. The keywords used were hepatocellular carcinoma, liver transplantation, expanded.

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Indeed, several studies have shown that the differentiation degree and microvascular invasion represent direct indicators of the biologic progression of HCC, being associated with tumor recurrence and poor long-term survival 9, 11, 18, 39, 40, Living donor liver transplantation versus deceased donor liver transplantation for hepatocellular carcinoma: Estimates of worldwide burden of cancer in Stringent inclusion criteria have been hepatocarcioma to ensure tumor free survival after LT.

Their significance derives from a landmark study in 48 patients by Mazzaferro et al which showed that selecting cases for transplantation according to specific strict criteria led to improved overall and disease-free survival at a 4-year time point.

Up-to-seven criteria, Liver transplantation, Outcome, Hepatocellular carcinoma, Recurrence. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med.

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J Hepatol ; Several years later, based on greater experience, some groups argued that the Milan criteria should be expanded. National Center for Biotechnology InformationU.

Makuuchi M, Sano K. Detection of primary hepatic malignancy in liver candidates: Natural hystory of untreated nonsurgical hepatocellular carcinoma: Poor prognosis for hepatocellular carcinoma with transarterial chemoembolization pre-transplantation: The quandary over liver transplantation for hepatocellular carcinoma: Our data indicated that LDLT crierios performed more frequently in the Milan criteria group, so this selective bias did not affect the long-term survival rate.


Their results showed that the post liver transplantation survival rates were Several studies have shown that some tumor patients transplanted outside of the UNOS and MC survive longer 9, 12, 16, 17, 18, 36, 44, 52 and as consequence, several proposals have been made to expand the HCC inclusion criteria 18, 28, 63, 64, Earlier presentation and application of curative treatments in hepatocellular carcinoma.

The influence of comorbidities, age, and performance status on the prognosis and treatment of patients with metastatic carcinomas of unknown primary site: Inguinal hernia surgery Femoral hernia repair. All of the tumor characteristics were evaluated by histological examination.

Milan criteria

The length of follow-up for all the patients in our study was at least 5 years, and no significant differences were observed among the groups. Doxorubicin-eluting bead vs conventional transcatheter arterial chemoembolization for hepatocellular carcinoma before liver transplantation.

Listing criteria for HCC should mlian the minimum acceptable recurrence-free survival rate and must reflect a consensus of transplantation community. Hepatocellular carcinoma in elderly patients: Lung and brain 1 caselung and spine liver, lung and bone.

Prognostic prediction and treatment strategy in hepatocellular carcinoma.

Resection and liver transplantation for hepatocellular carcinoma. Sirolimus-based immunosuppression for liver transplantation in the presence of extended criteria for hepatocellular carcinoma. Clinical and pathologic features of hepatocellular carcinoma in young and older Italian patients.

Liver transplantation and expanded Milan criteria: does it really work?

Some have advocated criterils the use of expanded guidelines for liver transplantation in the setting of HCC. A future randomized study would be the best way to evaluate the effectiveness of the up-to-seven criteria as inclusion criteria for HCC LT.


Several years later, based on greater experience, some groups argued that the Milan criteria criteros be critrrios, as a substantial number of patients with HCC exceeding these criteria could also greatly benefit from transplantation[ 6 – 10 ]. Liver transplantation and expanded Milan criteria. Systematic review of randomized trials for unresectable hepatocellular carcinoma: We retrospectively collected the data of these three groups and then compared their baseline characteristics, intraoperative data, post-operative recovery and long-term survival, including the overall survival, tumor-free survival and recurrence rate.

Effective management of early HCC includes resection, radiofrequency ablation and liver dr LT. Liver transplant results for hepatocellular carcinoma applying strict preoperative selection criteria.

Articles with incomplete citations from December All articles with incomplete citations All articles lacking reliable references Articles lacking reliable references from December From Wikipedia, the free encyclopedia. There were no significant differences among three groups with respect to recipient gender, age, or body mass index BMI.

The Criherios proposal is the approach mostly tested; however, it has been challenged because of the use of explants pathology. Liver transplantation for adult patients with hepatocellular carcinoma in Korea: Pretransplantation evaluation of the cirrhotic liver with explantation correlation: Hospital Universitario 12 de Octubre.

A systematic search of Medline PubMED database was performed to identify studies evaluating expanded criteria for patients with HCC submitted to liver transplantation. Donor safety in crriterios donor liver transplantation: Liver transplantation versus liver resection for hepatocellular carcinoma: Llovet JM, Bruix J. J Gastroenterol Hepatol ;