Correspondence from The New England Journal of Medicine — Cellulitis. To the Editor: In their article on the Prophylactic Antibiotics for the Treatment of Cellulitis at Home I (PATCH I) trial, Thomas et al. (May 2 issue)1 report that the. In a recent retrospective study of patients who were hospitalized with presumed cellulitis, dermatologists concluded that roughly 30% of.

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Comment in N Engl J Med. We conducted a double-blind, randomized, controlled trial involving patients with two or more episodes of cellulitis of the leg who were recruited in 28 hospitals in the United Kingdom and Ireland. Is it chronic changes of venous stasis and chronic ulceration? Skip to main content.

Penicillin to prevent recurrent leg cellulitis.

A total of patients were recruited. Leg Ulcers and recurrent cellulitis.

Refer for specialist opinion if severe infection Is it cellulitis? Participants were followed for up to 3 years.


Are they suitable for compression? N Engl J Med.

Amiodarone and drugs which prolong the QT interval can interact with many antibiotics. Comments from Expert Advisory Committee Cellulitks do not improve healing unless active infection. Treat tinea pedis or candida infection with topical terbenifine or miconazole respectively. Cellulitis of the leg is a common bacterial infection of the skin and underlying tissue. Review antibiotics after culture results.

Leg Ulcers and recurrent cellulitis

Because the risk of recurrence was not constant over the 3-year period, the primary hypothesis was tested during prophylaxis only. Statins can interact with some antibiotics and increase the risk of rhabdomyolysis. Penecillin to prevent leg cellulitis NEJM ; We compared prophylactic low-dose penicillin with placebo for the prevention of recurrent cellulitis. Baseline characteristics were similar in the two nemj. Please refer to our Drug Interactions Table for further information.

Overall, participants nrjm the penicillin group had fewer repeat episodes than those in the placebo group vs. Colonisation is likely in leg ulcers.

Leg Ulcers and recurrent cellulitis –

Bilateral cellulitis is uncommon. Prophalactic antibiotics for the prevention of cellulitis erysipelas of the leg: In patients with recurrent cellulitis of the leg, penicillin was effective in preventing subsequent attacks during prophylaxis, but the protective effect diminished progressively once drug therapy was stopped.


Antibiotics do not improve cellulitsi unless active infection. Doses are oral and for adults unless otherwise stated. Many antibiotics increase the risk of bleeding with anticoagulants.

Randomization was performed according to a computer-generated code, and study medications penicillin [ mg twice a day] or placebo for 12 months were dispensed by a central pharmacy. The median time to a first recurrence of cellulitis was days in the penicillin group and days in the placebo group. The primary outcome was the time to a first recurrence.