The effect of hydro-alcoholic celery (Apium graveolens) leaf extract on cardiovascular parameters and lipid profile in animal model of hypertension induced by. Abstract: Apium graveolens (celery) is an edible and traditionally medicinal plant worldwide, among others for the treatment of hypertension. Celery (Apium graveolens L., Apiaceae) is one of the popular aromatic mean arterial blood pressure and heart rate in normotensive and hypertensive rats.

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Roselle primes the vasorelaxant pathways of both endothelial cells Ajay et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension.

Cardiovascular activity of Labdane Diterpenes from andrographis paniculata in isolated rat hearts.

New perspectives on how to discover drugs from herbal medicines: In addition to apiu, antioxidant Lobo et al. I ncreased blood graveolena BP is one of the important risk factors for coronary heart disease, which is the largest cause of mortality in industrial countries. Systolic blood pressure was measured by means of the tail-cuff method using a SP MLT physiological pressure transducer. Camellia sinensis tea Collectively, the teas prepared from Camellia sinensis are the most frequently consumed beverages and are second only to water, worldwide Faria et al.

Protective effect of extract of Crataegus pinnatifida pollen on DNA damage response to oxidative stress.

Anti-hypertensive Herbs and their Mechanisms of Action: Part I

Apart from its vasodilatory capacity, danshen expresses additional anti-hypertensive parameters such as antioxidative, anti-proliferative, and anti-inflammatory activities. Bythe annual death toll is estimated to reach Protective effects of saffron Crocus sativus Linn. Green tea attenuates oxidative stress and downregulates the expression of angiotensin II AT 1 receptor in renal and hepatic tissues of streptozotocin-induced diabetic rats.


Hexanic extract was by far the more potent in lowering BP in comparison to other solvent extracts. The use of herbal therapies for treatment and management of cardiovascular diseases CVDs is increasing.

Danshen’s most effective components include: Papademetriou V, et al. Stage 1 and 2 hypertensive humans. This is due to several factors, principal of which is that herbal medicine is a cheaper alternative with fewer undesired side effects Frishman et al. BeCl 2 -treated Wistar rats.

Mild to moderate hypertension. This present study supports scientific evidence of the plant as anti hypertensive agent. Inhibition of angiotensin convertin enzyme ACE activity by the anthocyanins delphinidin- and cyanidinO-sambubiosides from Hibiscus sabdariffa.

Antihypertensive Effect of Celery Seed on Rat Blood Pressure in Chronic Administration

Fructose, insulin resistance, and metabolic dyslipidemia. Conclusion With CVD remaining as a leading cause of worldwide mortality, the search for more effective treatments ought to be of prime importance. Insulin gene expression pattern in rat pancreas during the estrous cycle. Garlic components inhibit angiotensin II-induced cell-cycle progression and migration: Principles and Practice of Phytotherapy. Support Center Support Center. Introduction Cardiovascular disease CVD remains the leading cause of debility and premature death WHO,and hence a major public health problem.

Saffron’s antioxidant ability has also been widely reported. Zingiber officinale ginger Ginger, a very common culinary ingredient, is reported to possess hypotensive properties. This in itself is a selective oxidant and can precipitate oxidative stress as well as diminish the vasodilatory effect of NO Drummond et al.

NBP is one of the active constituents in celery. Along the same line, another randomized, double-blind, crossover trial reported that central SBP and DBP of healthy subjects was significantly reduced by 4. Cellular effects of garlic supplements and antioxidant vitamins in lowering marginally high blood pressure in humans: Indeed, the lack of sufficient clinical trials constitutes a significant limitation on their use at the present time.

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Cardiovascular and metabolic effects of Berberine. Received Nov 11; Accepted Feb 6. Effectively, this yields more superoxide anion that eventually depletes BH 4. Acknowledgment The authors gratefully acknowledge the Vice Chancellor of Research, Mashhad University of Medical Sciences for financial support through grant number Pharmacological actions of pungent constitutents, 6 -gingerol and 6 -shogaol. In Vitr Mol Toxicol.

Vasorelaxant and antihypertensive effects of methanolic extract from roots of Laelia anceps are mediated by calcium-channel antagonism.

Chronic NF-kappaB blockade improves renal angiotensin II type 1 receptor functions and reduces blood pressure in Zucker diabetic rats. Triterpenoids and flavonoids from celery Apium graveolens J Nat Prod. Role of natural herbs in the treatment of hypertension.

National Center for Biotechnology InformationU. Celery-based topical repellents as a potential natural alternative for personal protection against mosquitoes.

Suppression of oxidative stress and pro-inflammatory mediators by Cymbopogon citratus Hypertesnion.

Tehran University Medical Journal

Below we discuss some of the major mechanisms implicated in the pathogenesis of hypertension. Singapore medical journal, 47 Celery grows up to 1-m height and has odd-pinnate compound leaves with dentate leaflets on a central stem.

This fact will be highlighted in different sections of this review.